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Lincosamides (eg.
lincomycin, clindamycin) are a class of drugs which bind to 50S
subunit of bacterial ribosomes and inhibit early elongation
of peptide chain by inhibiting transpeptidase reaction. In
this sense they have a similar action to
macrolides.
Resistance
Target bacteria may alter the drug's target site (similar to resistance found in macrolides and streptogramins). Also, enzymatic inactivation of clindamycin has been described (rare).
Pharmacodynamics
These are bacteriostatic drugs and antagonists of macrolides and streptogramins.
Further reading
- Van Bambeke F. Mechanisms of action. In Armstrong D, Cohen J. Infectious diseases. Mosby, London, 1999, pp7/1.1-7/1.14
