Drugs & Medication

Phenothiazine
General
Systematic name	10H-phenothiazine
Other names	thiodiphenylamine, dibenzothiazine
Molecular formula	C12H9NS
SMILES	?
Molar mass	199.2762 g/mol
Appearance	yellow rhombic leaflets or diamond-shaped plates
CAS number	92-84-2
Properties
Density and phase	? g/cm3, solid at STP
Soluble	benzene, ether, hot acetic acid, ethanol (slightly), mineral oil (slightly)
Insoluble	water, petroleum ether, chloroform
Melting point	185 °C
Boiling point	371 °C
Acidity (pKa)	approx 23 in DMSO
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)

Phenothiazine (a phenol derivative of thiazine) is a pesticide and industrial chemical used in pharmaceutical manufacturing. It is sometimes used as an antihelminthic. It was introduced by DuPont as an insecticide in 1935. It is now most commonly used as an intermediate chemical in the manufacture of various psychiatric drugs.

Phenothiazine-derivative drugs

The word "phenothiazines" is used to describe the largest of the five main classes of antipsychotic drugs. Although these drugs are generally effective, there are often serious side effects including tardive dyskinesia and sedation (especially in the early stages of treatment).

There are three groups of phenothiazines, differing by their chemical structure and their pharmacological effects:

References

• PubChem Substance Summary: Phenothiazine National Center for Biotechnology Information.

1. ↑  History of Insecticides and Control Equipment Clemson University Pesticide Information Program.
2. ↑  Hendricks, Christensen, J.B., and Kristiansen, Jette E. Sonderborg, Denmark. "Antibakterielle Eigenschaften der Phenothiazine: Eine Behandlungsoption für die Zukunft?" Chemotherapie Journal. 13.5. (2004): 203–205. Wissenschaftliche Verlagsgesesellschaft mbH. 21 August 2005. (PDF).